Wolffe, formerly designated CC-3636, was a veteran Clone Commander in the Grand Army of the Republic who served with Jedi General Plo Koon during the Clone Wars. The leader of the 104th Battalion's famed Wolfpack Squad, Commander Wolffe proved to be tireless in his efforts against the Confederacy of Independent Systems, displaying an affinity for strategy, as well as perception.
On his first mission with Koon, Wolffe served on board the Jedi Master's flagship, the 'Triumphant', when Koon led a task force to eliminate the Separatist warship 'Malevolence'. While confronting the Malevolence in the Abregado System, all the Troopers from the Battalion who were on board the ship were eliminated, save for Koon, Wolffe, Clone Sergeant "Sinker" and Trooper CT-4860 "Boost". The four were rescued by Jedi General Anakin Skywalker and his Padawan, Ahsoka Tano, and Wolffe later had his unit adopt new Clone Trooper armor in honor of his fallen comrades: going from maroon red to steel grey.
Refusing to let the loss of the Wolfpack deter him from his service, he inspired loyalty amongst the new Troopers to his command.
During the Battle of Khorm, Wolffe lost his right eye in a fight with the Sith Apprentice Asajj Ventress, and he subsequently wore a cybernetic eye replacement and retained a facial scar.
Wolffe continued his military service despite his injuries to the Republic, undertaking several key missions with Koon, working with Skywalker and Tano again during the Battles on Felucia, rescuing Skywalker and Jedi Master Mace Windu on Vanqor, and helping a Republic strike team escape with rescued prisoners from Lola Sayu. He personally oversaw a supply mission to the groundquake-devastated planet Aleen, assisting in liberating Togruta slaves from the Zygerrian Slave Empire on Kadavo, and took part in a mission that recovered the Lightsaber of the late Jedi Master Sifo-Dyas.
Fifteen years after the end of the Clone Wars, Wolffe was still alive and was living in a modified AT-TE on Seelos with Clone Captain CT-7567 "Rex" and Clone Commando Captain CT-5576 "Gregor". All three had survived and in time had their inhibitor chips removed, though doing so left lasting physical, mental and emotional damage to the Commander.
At one point, the group was visited by the Spectres, a Rebel group that was combating the Galactic Empire. Wolffe initially distrusted the group, which included the Great Jedi Purge survivor Kanan Jarrus (actually Caleb Dume) among their number. Believing that the Rebels were a threat, Wolffe sent a transmission that was picked up by the Imperial Security Bureau Agent Kallus, alerting the Empire of the Rebel presence. However, Wolffe came to see reason when Rex spoke up for the Rebels and told him they were not a threat.
Under Rex's command, Wolffe and Gregor held back Kallus's AT-AT Walkers so that the Rebels could escape. Following the battle, he and Gregor stayed behind on Seelos while Rex joined the Rebellion.
In 0 BBY, Wolffe and Gregor joined Rebel Forces on Lothal and contributed to the liberation of the planet.