A member of the Orsini family, Franciotto Orsini was born in Rome in 1473, the son of Orso Orsini di Monteredondo and Costanza Savelli.Biography from the Biographical Dictionary of the Cardinals of the Holy Roman Church He was a nephew of Pope Leo X on his father's side. Orsini was educated in Florence by Lorenzo de' Medici.
Angels of Vengeance's
Early in his life, he participated in several military exercises, fighting against the forces of Cesare Borgia. He married Violante Orsini di Mugnano and had five legitimate children. After his wife's death, he entered the ecclesiastical estate.
Moving to Rome, he became a protonotary apostolic.
The Orsini Family
His uncle Pope Leo X made him a cardinal deacon in the consistory of July 1, 1517. He received the red hat and the deaconry of San Giorgio in Velabro on July 6, 1517.
He was administrator of the see of Nicastro from September 15, 1517 to May 5, 1518. He became archpriest of St. Peter's Basilica. On January 18, 1519, he was named administrator of the see of Boiano, holding this post until July 24, 1523. He was deposed from the cardinalate on August 8, 1519, though later reinstated. Sometime after 1519, he opted for the deaconry of Santa Maria in Cosmedin.
He participated in both the papal conclave of 1521-22 that elected Pope Adrian VI, and in the papal conclave of 1523 that elected Pope Clement VII.
On June 15, 1524, he became administrator of the see of Fréjus, holding this post until December 15, 1525. He was the administrator of the see of Rimini from March 23, 1528 until April 7, 1529.
He died in Rome on January 10, 1534. He is buried in St. Peter's Basilica.
This line was initiated by Guido Orsini, second son of Romano, who inherited the county of Soana, on the western side of Lake Bolsena in southern Tuscany. He and his descendants ruled over the fiefs of Soana, Pitigliano and Nola, but in the early 15th century wars against the Republic of Siena and the Colonnas caused the loss of several territories. Bertoldo (died 1417) managed to keep only Pitigliano, while his grandson Orso (died July 5, 1479) was count of Nola and fought as condottiere under the Duke of Milan and the Republic of Venice. Later he entered the service of Ferdinand I of Naples, but, not having taken part in the Barons' conspiracy, he was rewarded with the fiefs of Ascoli and Atripalda. He took part in the Aragonese campaign in Tuscany and was killed at the siege of Viterbo.
The most outstanding member of the Pitigliano line was Niccolò, one of the major condottiere of the time. His son Ludovico (died January 27, 1534) and his nephew Enrico (died 1528) participated in the Italian Wars at the service of both France and Spain, often changing side with the typical ease of the Italian military leaders of the time. Two of Ludovico's daughters married relevant figures: Geronima to Pier Luigi Farnese, illegitimate son of Pope Paul III and Marzia to Gian Giacomo Medici of Marignano, an important general of the Spanish army.
The line started to decay after the loss of Nola by Ludovico, who was also forced to accept the Sienese suzerainty over Pitigliano. Under his son Giovan Francesco (died May 8, 1567) the county entered the orbit of the Grand Duke of Tuscany. Later, the attempt of Alessandro (died February 9, 1604) to obtain the title of Monterotondo was thwarted by Pope Gregory XIII. His son Giannantonio (March 25, 1569 – 1613) sold Pitigliano to Tuscany, in exchange for the marquisate of Monte San Savino.
The line became extinct in 1640 with the death of Alessandro.