Eight years after the explosion of Flight 180, seven years after the Route 23 pileup and three years after Devil's Flight derailment, college student Nick O'Bannon has a premonition of a car crash while watching a race at McKinley Speedway for a study break, which sends debris into the audience, crushing some spectators and resulting in the stadium partially collapsing, killing almost everyone present in the 180 section. In a panic, Nick convinces his girlfriend Lori Milligan, and friends Hunt Wynorski and Janet Cunningham to leave, with the quartet being followed by a handful of others who become angry with Nick after he pushes past them to escape. A security guard named George Lanter intervenes when everyone begins to argue outside, just as the catastrophe Nick had foreseen occurs.
Minutes later, a flying tire comes out and obliterates Nadia Monroy. After a memorial service at McKinley Speedway, Carter Daniels attempts to burn a cross on George's front lawn but his plan backfires, he is set on fire and violently dragged down the street by his own tow truck, he is then blown apart by it with his blown off head lands right next to George who goes to see what is happening. The next day Samantha Lane is killed when a lawn mower rides over a rock, thrown in its path by her sons which is then shot right through her eye. Before their deaths, Nick had seen omens of clues how they would die.
Hearing about Carter's and Samantha's deaths on the news, Nick and Lori begin doing research, and learn about the disasters that occurred in previous films and discover that the survivors who were saved by premonitions began dying in a series of improbable accidents shortly afterwards. While Hunt and Janet refuse to believe them, Nick and Lori manage to convince George that Death is after them and the trio begin trying to warn the other remaining survivors.
Nick, Lori, and George head over to Grandstate Customs to warn Andy Kewzer that he is next to die. Andy fails to believe, but moments later he is struck by an oxygen tank, and diced into a metal grid fence. After Andy's death, Nick goes to save Hunt, while Lori and George go to save Janet. They are successful in saving Janet from a malfunctioning car wash, but Nick is too late to save Hunt when his organs are sucked out of his anus by a pool drain.
Nick then believes that saving Janet had broken the chain, and Lori and Janet celebrate by going to see Love Lays Dying in a mall. Nick then realizes that another survivor, Jonathan Groves was found in the debris of the racetrack, and rushes to the hospital along with George. They fail to save Jonathan from being crushed by an overflowing bathtub, and moments later, George is hit by an ambulance. Nick then realizes it's up to him to save the girls, and rushes to the mall.
Once Nick arrives, he has another vision showing him that Lori and Janet will die while watching the film in the shopping mall cinema after an explosion in a room behind the theater. Nick rushes to reach them, while Lori begins spotting omens warning her that the danger is not over. Once Nick arrives, he and Lori attempt to convince Janet to leave, but are unsuccessful in their efforts. Janet is killed in the explosion within a shrapnel and Lori is splattered to death by the gears of a malfunctioning escalator while escaping. After the another premonition, Nick then realizes that the event hasn't happened yet but George dies which same predicted this another vision, and is able to save his friends by extinguishing the fire that would have caused the initial explosion.
The Present
It's been a year since the McKinley Speedway disaster. The trio has graduated college, and have discussed their plans for the future. Janet has learned to not take life for granted, now that she's been given a second chance. She's looking for a job in the field that she went to college for. Nick and Lori have discussed plans to get married and settle down together. Where the future takes them now, only fate will tell.
